2. Signaling Pathways
  3. Anti-infection
  4. Enterovirus

Enterovirus

Rhinovirus; HRV; HRVs; HEV; HEVs

Enterovirus

Related Products

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The genus Enterovirus (EV) belonging to the Picornaviridae family comprises 13 species, of which seven are human viruses. Four of the species are: (1) EV-A such as coxsackievirus (CV)-A6, CV-A10, CV-A16 and EV-A71, (2) EV-B such as the CV-B viruses, echoviruses (ECHO) and CV-A9, (3) EV-C such as polioviruses (PV) and CV-A21, (4) EV-D such as EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B and RV-C which comprised over 100 different numbered RVs. Infection with enteroviruses can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness.

Enteroviruses are small, nonenveloped, positive-sense, single-stranded RNA viruses with an icosahedral capsid. The genome of ∼7.5 kb encodes a single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, 3C, and 3D), and several functional processing intermediates. The viral nonstructural proteins, particularly the protease 3Cpro and the RNA-dependent RNA polymerase 3Dpol, are attractive targets for antiviral drug development.

Enterovirus Related Products (113):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15215
    Antiviral agent 64
    		Inhibitor
    Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC50 of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, HSV-1, and influenza virus H1N1, with EC50 of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively.
    Antiviral agent 64
  • HY-N15737
    Fukinolic acid
    		Inhibitor
    Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels.
    Fukinolic acid
  • HY-135165
    Hydrobenzole hydrochloride
    		Inhibitor
    Hydrobenzole hydrochloride is an antiviral agent. Hydrobenzole hydrochloride has antiviral activity against ECHO-12 virus.
    Hydrobenzole hydrochloride
  • HY-B0154S
    Fluticasone propionate-d3
    		Inhibitor
    Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
    Fluticasone propionate-d<sub>3</sub>
  • HY-172216
    EV-A71-IN-3
    		Inhibitor
    EV-A71-IN-3 (Compound IRE-03-3) is the inhibitor for Enterovirus A71 EV-A71 that targets internal ribosomal entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits the viral proliferation with an EC50 of 11.96 μM.
    EV-A71-IN-3
  • HY-101064S4
    Fmoc-leucine-15N
    		Inhibitor 98.5%
    Fmoc-leucine-15N is a 15N-labeled and 15N-labled Fmoc-leucine (HY-101064).
    Fmoc-leucine-<sup>15</sup>N
  • HY-174815
    Jun15799
    		Inhibitor
    Jun15799 is an Enterovirus (EVs) 2C protein (EVs 2C) inhibitor with Kis of 0.8, 21.1 and 3.0 μM for EV-D68, EV-A71 and CVB3, respectively. Jun15799 has a significant antiviral activity against EV-D68 US/MO/14-18947, EV-A71 Tainan/4643/1998 and CVB3 Nancy cells (EC50s of 0.3, 11.4 and 0.3 μM, respectively). Jun15799 can be used for viral infections research, such as meningitis, hand, foot and mouth disease (HFMD) and viral myocarditis.
    Jun15799
  • HY-162022
    BTA-188
    		Inhibitor
    BTA-188, a pyridazinyl oxime ether, is an orally active, potent inhibitor of rhinoviruses (HRV) and enterovirus (EV) 71 in vitro. BTA-188 inhibits HRV-2 replication with an IC50 of 0.8 nM and an IC90 of 11 nM. BTA-188 inhibits enterovirus with an IC50 of 82 and an IC90 of 109 nM. BTA-188 is a potential chemotherapeutic agent for infections caused by the viruses in the Picornaviridae.
    BTA-188
  • HY-D0205AR
    Carbocisteine (Standard)
    		Inhibitor
    Carbocisteine (Standard) is the analytical standard of Carbocisteine. This product is intended for research and analytical applications. Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD).
    Carbocisteine (Standard)
  • HY-B1030R
    Lanatoside C (Standard)
    		Inhibitor
    Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
    Lanatoside C (Standard)
  • HY-B1693R
    Levomepromazine (Standard)
    		Inhibitor
    Levomepromazine (Standard) is the analytical standard of Levomepromazine. This product is intended for research and analytical applications. Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting.
    Levomepromazine (Standard)
  • HY-W012017R
    2-Hydroxytetradecanoic acid (Standard)
    		Inhibitor
    2-Hydroxytetradecanoic acid is a hydroxy fatty acid that inhibits cleavage between the enterovirus capsid proteins VP4 and VP2. 2-Hydroxytetradecanoic Acid has anti-virus activity.
    2-Hydroxytetradecanoic acid (Standard)
  • HY-106774
    R-61837
    		Inhibitor
    R-61837 is a synthetic antirhinoviral compound with significant in vitro activity. R-61837 is 10 times and 57 times more active against human rhinovirus type 9 (HRV-9) than Enviroxime and dichloroflavone (DCF), respectively, and is more active against human rhinovirus type 2 (HRV-2 ) were 5 times and 10 times higher respectively.
    R-61837
  • HY-175165
    Jun6504
    		Inhibitor
    Jun6504 is an enterovirus 2C inhibitor. Jun6504 shows potent and broad-spectrum antiviral activity against multiple strains of EV-D68 (EC50 = 250 nM), EV-A71 (EC50 = 502.4 nM), and CVB3 (EC50 = 1049 nM). Jun6504 improves paralysis score and weight gain in a neonatal mouse model of EV-D68 infection. Jun6504 reduces viral titers in the spinal cord and the infected quadriceps muscle. Jun6504 can be used for EV-D68 antiviral research.
    Jun6504
  • HY-N7108R
    7-Hydroxyflavone (Standard)
    		Inhibitor
    7-Hydroxyflavone (Standard) is the analytical standard of 7-Hydroxyflavone. This product is intended for research and analytical applications. 7-Hydroxyflavone is a flavonoid isolated from Clerodendrum phlomidis, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. 7-Hydroxyflavone inhibits PKM2 with an IC50 of 2.12 μM. 7-Hydroxyflavone inhibits COX-2 and 5-LOX with IC50 of 27 µg/mL and 33 µg/mL. 7-Hydroxyflavone is orally active.
    7-Hydroxyflavone (Standard)
  • HY-175557
    PI4K-IN-2
    		Inhibitor
    PI4K-IN-2 (Compound 30) is a highly selective type III phosphatidylinositol 4-kinase β (PI4KB) inhibitor (IC50=0.015 μM). PI4K-IN-2 is promising for research of human rhinovirus (HRV).
    PI4K-IN-2
  • HY-100679S
    Pirlindole-d4
    Pirlindole-d4 is the deuterium labeled Pirlindole.
    Pirlindole-d<sub>4</sub>
  • HY-100679R
    Pirlindole (Standard)
    		Inhibitor
    Pirlindole (Standard) is the analytical standard of Pirlindole. This product is intended for research and analytical applications. Pirlindole is a selective and reversible MAO-A inhibitor. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3).
    Pirlindole (Standard)
  • HY-106161S1
    Rupintrivir-d7
    		Inhibitor
    Rupintrivir-d7 is a deuterated labeled Rupintrivir. Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.
    Rupintrivir-d<sub>7</sub>
  • HY-N14780
    Pochonin D
    		Inhibitor
    Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers.
    Pochonin D